Phosphopantetheine attachment site

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August undefined, 2024

WebAug 1, 2015 · Phosphopantetheine attachment site: Dieckmanna Cyclase (DKC) NADB-Rossmann: I3810-R4092: NAD(P)-binding motif: ORF3 (fumoA) encodes a cytochrome P450 monooxygenase which maybe catalyzes an unprecedented oxidative ring expansion of prefumosorinone A to form the 2-pyridone core of fumosorinone (Halo et al., 2008a). … Webphosphopantetheine (or pantetheine 4' phosphate) (Ppant) prosthetic group that is covalently attached to an invariant serine residue of the CP domain. CP domains, typically consisting of 70-100 residues, are either freestanding or embedded in these multifunctional proteins and exist as three variants: an

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Phosphopantetheine, also known as 4'-phosphopantetheine, is a prosthetic group of several acyl carrier proteins including the acyl carrier proteins (ACP) of fatty acid synthases, ACPs of polyketide synthases, the peptidyl carrier proteins (PCP), as well as aryl carrier proteins (ArCP) of nonribosomal peptide synthetases (NRPS). It is also present in formyltetrahydrofolate dehydrogenase. WebACP phosphopantetheine attachment site binding involved in fatty acid biosynthetic process Alternate IDs None Definition Binding an acyl group and presenting it for processing or offloading to a cognate enzyme. Covalently binds the acyl group via a phosphopantetheine prosthetic group and mediates protein-protein interactions with the enzyme ... razor sharp barber shop milwaukee wi

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WebMar 23, 2024 · It has 12 putative transmembrane domains and intracellular N and C termini. SLC26A1 contains a sulfate transporter signature, a phosphopantetheine attachment site, … WebThe human NDUFAB1 protein contains a phosphopantetheine attachment site (DLGLDSLDQVEIIMAM), unique for acyl carrier proteins, and an EF-hand calcium binding … WebNov 13, 2013 · 4ihh: Chasing acyl carrier protein through a catalytic cycle of lipid A production. simpson warehouse

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PhytoMine: GOTerm GO:0000036 ACP phosphopantetheine attachment site …

WebMay 28, 2010 · The amino acid sequence of NDRG1/Cap43 has been reported to bear a phosphopantetheine attachment site, an α/β hydrolase fold and three tandem repeats [15], [19], as well as a few sites that are phosphorylated by SGK [20] (Fig. 1 A). Western blotting revealed that NDRG1/Cap43 protein had several bands with different mobilities, including … http://amigo.geneontology.org/amigo/term/GO:0000036 razorsharp barbershop elthamWebJan 10, 2024 · To obtain active CAR enzyme, a phosphopantetheine group must be attached covalently to a conserved serine in the PCP domain mediated by a suitable … simpson warranty australia

"WebAug 23, 2024 · PDOC00012 1 Phosphopantetheine attachment site PDOC00013 1 Prokaryotic membrane lipoprotein lipid attachment site PDOC00342 1 Prokaryotic N … " - Phosphopantetheine attachment site

Phosphopantetheine attachment site

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WebPhosphopantetheine attachment site Provide feedback. A 4'-phosphopantetheine prosthetic group is attached through a serine. This prosthetic group acts as a a 'swinging arm' for the attachment of activated fatty acid and amino-acid groups. This domain forms a four helix bundle. This family includes members not included in Prosite. WebPhylogenetic analysis of CARs. A) Domain organization of CAR sequences: adenylation domain (PFam PF00501), phosphopantetheine (PP) attachment site (PF00550), reductase domain (PF07793). B)...

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WebOct 1, 2024 · Genome sequencing, comparative genomic analysis, and gene disruption of Streptomycessp. SYP-A7193 showed that the inthomycin biosynthetic gene cluster (itm) belonged to the hybrid polyketide synthase (PKS)/nonribosomal peptide … WebPhosphopantetheine tethering is a posttranslational modification that takes place on the active site serine of carrier proteins138 – ‘acyl carrier proteins (ACPs) and peptidyl carrier proteins (PCPs), also termed thiolation (T) domains’ – during the biosynthesis of fatty acids (FAs) (use ACPs) ( Scheme 23 ), polyketides (PKs) (use ACPs) ( Scheme …

WebDownload scientific diagram Phylogenetic analysis of CARs. A) Domain organization of CAR sequences: adenylation domain (PFam PF00501), phosphopantetheine (PP) … Web[0005] This invention relates to a method of treatment, in particular to a method for lowering blood pressue levels in mammals and to compounds and compositions for use in such me

WebJan 17, 2024 · Among the 7 domains, the acyltransferase domain and phosphopantetheine attachment site showed the highest number of hydrogen bonds with gallic acid, i.e., 7/6 and 3/1 in hexanoic acid, respectively. According to our findings, gallic acid has a stronger binding affinity in these two domains than hexanoic acid since GA needs less binding … WebJan 6, 2024 · The Psc_Aza_B gene is predicted to encode a non-reducing polyketide synthase composed of ve modules: ACP transacylase, β-ketoacyl synthase, acyltransferase phosphopantetheine attachment site and ...

WebACP phosphopantetheine attachment site binding involved in fatty acid biosynthetic process Alternate IDs None Definition Binding an acyl group and presenting it for processing or …

http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00823 razor sharp barber shop toledo ohioWebJul 17, 2024 · The PCP Ser702, which serves as the phosphopantetheine attachment site, is positioned 52 Å away from the bound AMP phosphate. By contrast, ... razor sharp barber shop lexingtonWebSep 1, 2000 · Motifs I and III have been associated with ATP-binding and hydrolysis activities, respectively, since motif X contains a conserved serine to which a 4′-phosphopantetheine cofactor is very probably attached [ 3 ]. razor sharp barbershop mcallen txWebPromotional Article Monitoring. Register your specific details and specific drugs of interest and we will match the information you provide to articles from our extensive database and email PDF copies to you promptly. razor sharp battle creekWebDefinition: Interacting selectively and non-covalently with the attachment site of the phosphopantetheine prosthetic group of an acyl carrier protein (ACP) as part of the process of fatty acid biosynthesis. ID: GO:0000036 Synonyms: Articles referencing this term. Type II polyketide synthases: gaining a deeper insight into enzymatic teamwork ... simpson warranty doorsWebThe bond was not formed in a point mutant lacking the phosphopantetheine attachment site. Competition experiments with various amino acids indicated that the reaction was … razor sharp barb wireWebFeb 20, 2024 · In addition, the phosphopantetheinylation of ACPs is dependent on the co-enzyme A, the PPT enzyme and the conserved serine residue in the phosphopantetheine attachment site (Supplementary Fig. 3 ... simpson warranty registration