Phomopsidin

Author: njsn

August undefined, 2024

WebMar 1, 2004 · Phomopsidin, a known inhibitor of beta-tubulin that targets the eukaryotic cytoskeleton, inhibited the pathogen, but also showed mild cytotoxic effects. WebJan 1, 2004 · A Chemoenzymatic Synthesis of the cisDecalin Core Associated with the Novel AntiMitotic Agent Phomopsidin: Some Observations Concerning a High-Pressure-Promoted Diels–Alder Cycloaddition Reaction...

First Total Synthesis of Antimitotic Compound, (+)‐Phomopsidin.

WebPhomopsin A C36H45ClN6O12 CID 6438581 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities ... WebCarneic acids A and B (1, 2) are polyketide antibiotics structurally related to phomopsidin. They were isolated as major constituents of the stromata of Hypoxylon carneum, a species that had shown a highly specific secondary metabolite profile in a survey of xylariaceous ascomycetes based on HPLC profiling. Their chemical structures were elucidated by a … open mri southaven ms

Synthesis of NH006 - A photostable fungicide ... - Waseda University

WebJan 24, 2009 · In 1997, (+)-phomopsidin ( Fig. 1) was isolated from a marine-derived fungus, Phomopsis sp. strain TUF 95F47, that was collected in Pohnpei. 1 (+)-Phomopsidin was found to be a new inhibitor of microtubule assembly, showing strong inhibitory activity against the assembly of microtubule proteins derived from the porcine brain at an IC 50 of … WebPhomopsidin, a New Inhibitor of Microtubule Assembly Produced by Phomopsis sp. Isolated from Coral Reef in Pohnpei MICHIO NAMIKOSHI , HISAYOSHI KOBAYASHI , TAKESHI … WebJan 24, 2009 · This manuscript describes an alternative synthetic approach for (+)-phomopsidin, which shows strong inhibitory activity against the assembly of microtubule proteins. We observed that the TADA... open mri shirlington

Absolute structure, biosynthesis, and anti-microtubule …

Phomopsidin TargetMol

WebNov 21, 2024 · Metabolite profiling of this crude extract tentatively revealed the presence of the following secondary metabolites: 1,8-dihydroxynaphthalene (1), anserinone B (2), phelligridin B (3), metacytofilin (4), phomopsidin (5) and vermixocin A (6). Compounds 2 and 3 have been shown to be cytotoxic in literature. WebSep 19, 2024 · It has been reported that the origin of carbons in phomopsidin ( 3) was built by nine acetates and three methyl groups from l -methionine by feeding experiment with 13 C-labeled precursors [25]. A similar biogenesis has also been proposed for carneic acids A and B [27] and lovastatin [28]. ipaddrshowWebAbstract The absolute configuration of phomopsidin, a marine-derived fungal metabolite from Phomopsis sp. isolated at Pohnpei, was determined by the exciton chirality method as 6S, 7S, 8S, 11S, 12R, and 15R. The biosynthetic study using 13C-labeled precursors revealed the origin of all carbon atoms in phomopsidin, which was built by nine acetates and three … ip addr show dns

"WebThey appear to be species-specific marker molecules in H. carneum from different geographic regions, but do not constitute major metabolites of more than 100 species of … " - Phomopsidin

Phomopsidin

Carneic acids A and B, chemotaxonomically significant ... - PubMed

WebThis manuscript describes an alternative synthetic approach for (+)-phomopsidin, which shows strong inhibitory activity against the assembly of microtubule proteins. We observed that the TADA reaction of the macrolactone 5 with the reversed C11 configuration provided the desired cycloadduct 6 in 86% yield with excellent stereoselectivity (dr=16:1). WebAbstract. (Equation presented) The first total synthesis of (+)-phomopsidin has been achieved via a diastereoselective transannular Diels-Alder (TADA) reaction. Key steps in …

Did you know?

WebDec 5, 2012 · The Journal of Antibiotics - Identification of a new phomoxanthone antibiotic from Phomopsis longicolla and its antimicrobial correlation with other metabolites during … Webphosphamidon: [noun] a contact and systemic organophosphorus insecticide and miticide C10H19ClNO5P.

WebJun 1, 2024 · Phomopsidin, a known inhibitor of beta-tubulin that targets the eukaryotic cytoskeleton, inhibited the pathogen, but also showed mild cytotoxic effects. WebJun 29, 2004 · Read "First Total Synthesis of Antimitotic Compound, (+)‐Phomopsidin., ChemInform" on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.

WebJan 20, 2003 · Read "Absolute Structure, Biosynthesis, and anti‐Microtubule Activity of Phomopsidin, Isolated from a Marine‐Derived Fungus Phomopsis sp., ChemInform" on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.

WebThe absolute configuration of phomopsidin, a marine-derived fungal metabolite from Phomopsis sp. isolated at Pohnpei, was determined by the exciton chirality method as 6S, …

WebPhomopsidin C21H30O3 CID 10381991 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, … ip addr modifyWebDec 5, 2012 · The Journal of Antibiotics - Identification of a new phomoxanthone antibiotic from Phomopsis longicolla and its antimicrobial correlation with other metabolites during fermentation ip addr show dev loWebApr 24, 2024 · During a survey of xylarialean fungi in Northern Iran, several specimens that showed affinities to the Hypoxylon rubiginosum complex were collected and cultured. A comparison of their morphological characters, combined with a chemotaxonomic study based on high performance liquid chromatography, coupled with diode array detection … open mri south jerseyWebMK8383, isolated from Phoma sp. T2526 in 1993, exhibits potent antibiotic activities against a variety of phytopathogens and has been considered a promising fungicide against Botrytis cinerea. Unfortunately, MK8383 is a photosensitive compound and it … open mri thomson gaWebApr 24, 2024 · found to produce the anti-fungal beta-tubulin inhibitor phomopsidin in dual cul-ture with virulent strains of the pathogen. is compound was rst reported from a . open mri sheboygan wiWebFeb 19, 2004 · [reaction: see text] The first total synthesis of (+)-phomopsidin has been achieved via a diastereoselective transannular Diels-Alder (TADA) reaction. Key steps in the synthesis include diastereoselective ynone reduction with (-)-alpha-pinene and 9-BBN, macrocyclization by E-selective intramolecular … open mri scanner peterboroughWebPhomopsidin. Catalog No. T125428 CAS 199173-60-9. All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use. Phomopsidin, CAS 199173-60-9 Please contact us for prices and availability for the specification of product you are interested at. Product consultation. Get quote ... open mri south windsor ct