Cinnamic acid inhibition cancer cells

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August undefined, 2024

WebMar 10, 2024 · Two possible mechanisms were considered [ 17 ]: 1) CA activates the human peroxisome proliferator and nuclear receptor to inhibit oncogene (may be c-myc) amplification and expression of other genes; 2) CA blocks the posttranslational modification of cell growth-regulating proteins, such as certain p21ras protein, that is, preventing … WebThe potential of cinnamic acid as an anti-inflammatory and anti-cancer agent has been studied previously. In our investigation, novel bio-isosters of cinnamyl sulfonamide hydroxamate were synthesized, characterized and confirmed for their structure and evaluated for cytotoxicity. ... -2 and -3 showed cell-growth inhibition in 6 human cancer ...

Inhibition of histone deacetylases by trans-cinnamic acid …

WebBackground & objective: Recently, the research showed that cinnamic acid (CINN) could inhibit some cancer cells. This study was designed to investigate the effects of alpha … WebFeb 26, 2024 · Propolis extract or components was reported to be cytotoxic to several cancer cells [20, 21] and to induce autophagy in breast cancer cells [9].In order to elucidate whether and what kind of propolis components exhibits the above actions on prostate cancer CWR22Rv1 cells, the cytotoxic effects of eight cinnamic acid … dates from today

Cinnamic acid derivatives induce cell cycle arrest in carcinoma cell ...

WebCinnamic acid belongs to phenolic-acid class of polyphenols, one of the most abundant plant secondary metabolites. These substances are widely studied because of plethora … WebNov 1, 2024 · Thus, inhibition of CBR1 can increase the therapeutic effect of DOX. In the present study, we used a group of new synthetized cinnamic acid (CA) derivatives to … WebBackground/aim: Breast cancer is the second leading cause of cancer-related deaths in US, which necessitates constant research for medications with minimal adverse effects. … dates from today calculator

Effect and mechanism of action of cinnamic acid on …

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WebNov 30, 2024 · A search for naturally occurring HDAC inhibitors continues due to the adverse effects associated with known HDAC inhibitors like SAHA and TSA. Therefore … WebCinnamic acid containing an aryl ring with α, β-unsaturated ketone, was reported to have anticancer activity. Therefore, both chalcone and cinnamic acid have been adapted as versatile structural moieties in many cases of cancer drug development [ 30 ]. bizwebpattern.etudes.production.localWebPrevious studies have shown that trans-cinnamic acid (tCA) has a broad spectrum of biological activities, and exhibits antioxidant, anti-inflammatory and anticancer properties. … dates from to calculator

"WebJul 1, 2024 · In the current study, we show the inhibitory effects of cinnamic acid derivatives, including caffeic acid phenethyl ester (CAPE, 1), on the growth of breast and prostate cancer cells. Among the compounds examined, 3,4,5-trihydroxycinnamic acid … " - Cinnamic acid inhibition cancer cells

Cinnamic acid inhibition cancer cells

Synthesis of cinnamic acid ester derivatives with ... - ScienceDirect

WebCA can inhibit the growth of leukaemia cells by inducing cell apoptosis and significantly affected the cell cycle after 48 h treatment, resulting in increased G0/G1 phase and extension of thecell cycle in the tumour cells. This study aims to investigate the effect and mechanism of action of cinnamic acid (CA) on the proliferation and apoptosis of … WebApr 1, 2024 · We synthetized seventeen cinnamates derived from trans -cinnamic acid. • The Steglich esterification reaction was the main step involved in their synthesis. • The most effective compound 3q reduced the melanoma cell viability. • Compound 3q caused cell cycle arrest and apoptosis in B16-F10 cells. •

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WebMar 1, 2024 · Comprehensively, cinnamon and its constituents exhibit the anti-cancer and cancer prevention activities through various mechanisms: (1) anti-proliferation, (2) induction of cell death, (3) anti ... WebNov 30, 2024 · The anti-cancer activity of cinnamic acid derivatives was measured according to Madhunapantula et al., 2008 . 0.5 x 10 4 colon (HCT-116 and HCT-15) and …

WebMay 23, 2013 · The growth inhibition was probably associated with DNA damage leading to DNA synthesis inhibition, as shown by BrdU incorporation assay, induction of nuclear aberrations and then apoptosis. The frequency of cell death caused by cinnamic acid was higher in HT-144 cells. WebApr 10, 2024 · Cervical carcinoma is one of the most common cancers among women globally. Histone deacetylase inhibitors (HDACIs) constitute anticancer drugs that, by increasing the histone acetylation level in various cell types, induce differentiation, cell cycle arrest, and apoptosis. The aim of the current review is to study the role of HDACIs in the …

WebJul 24, 2010 · Conclusion: Our study suggests that anti-tumor effect of cinnamon extracts is directly linked with enhanced pro-apoptotic activity and inhibition of NFkappaB and AP1 … Webimportant in cancer treatment. Cinnamic acid (CA), a phenylalanine deamination product in plant tissue, is the main active ingredient extracted from food-flavouring ... suggesting …

WebSep 9, 2024 · Results: Cinnamic acid inhibited cell viability and cell invasion, as well as decreased ECAR and OCR, in primary endometrial stromal cells. Cinnamic acid …

WebJul 18, 2024 · The antioxidant and biological activities of Physalis peruviana have been reported in extracts of the calyxes, leaves, stems, and merely in fruits. These extracts have been shown to inhibit the growth of different cancer cell lines and exhibit protective effects in liver and other cells, as well as exhibit anti-inflammatory activity. 11,12 Some studies … dates from syriaWebP-Coumaric acid, an abundant isomer of cin- namic acid, inhibits the colon cancer cell lines by in- creasing the ROS levels, decreasing the mitochondrial membrane potential and inhibiting the cell cycle at sub G1 phase [52]. Esters of cinnamic acids are more potent when compared to the hydroxylated or the methoxylated versions [40]. dates from the end of the eighteenth centuryWebBackground: Berberine and cinnamic acid are natural compounds that exhibit potent anticancer activities through distinct molecular mechanisms. Objective: In the present study, we aimed to investigate the proapoptotic potential of cinnamic acid and berberine in cancer cells by examining their effect on the expression of proapoptotic and antiapoptotic genes. dates fruit and prostate cancer dates from moroccoWebDec 19, 2024 · Inflammation and oxidative stress are involved in cardiovascular diseases. Nitrogen monoxide participates in the regulation of endothelial processes. Thus, derivatives of classic nonsteroidal anti-inflammatory drugs (NSAIDs), trolox or cinnamic acids esterified with 2-(nitrooxy)ethanol were designed and studied. It was found that the nitrogen … dates from tunisiaWebMar 23, 2016 · For the inhibition of cancer cell proliferation, the concentration of tCA reaching mM levels was required; however, the study data verified that tCA interfered in histone acetylation via inhibiting HDAC, leading to cancer cell cytotoxicity. In addition, the therapeutic efficacy of tCA has been confirmed. ... Cinnamic acid induces apoptotic cell ... dates from the past stampsWebOct 21, 2024 · Incubation of human colorectal cancer cells in the presence of cinnamic acid at concentration higher than 10 mM resulted in reduced cell viability (IC50 13.6 mM). ... The mechanism is attributed to the lower expression of some drug resistance proteins, inhibition of cell proliferation, and promotion of apoptosis (Lu et al. 2024). dates from seed